Potentiometric CheqSol and standardized shake-flask solubility methods are complimentary tools in physicochemical profiling
نویسندگان
چکیده
منابع مشابه
Physicochemical profiling (solubility, permeability and charge state).
About 30% of drug candidate molecules are rejected due to pharmacokinetic-related failures. When poor pharmaceutical properties are discovered in development, the costs of bringing a potent but poorly absorbable molecule to a product stage by "formulation" can become very high. Fast and reliable in vitro prediction strategies are needed to filter out problematic molecules at the earliest stages...
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Chinese hamster ovary (CHO) cells is one of the most widely used production host for the commercial production of biopharmaceuticals product. They have been extensively studied and developed, and today provide a stable platform for producing monoclonal antibodies and recombinant proteins. This study focused on the production of recombinant protein in suspension culture of CHO cells in spinner f...
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ژورنال
عنوان ژورنال: European Journal of Pharmaceutical Sciences
سال: 2020
ISSN: 0928-0987
DOI: 10.1016/j.ejps.2020.105305